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Clavulanic Acid
🥰Excellent
Catalog No. T19860Cas No. 58001-44-8
Alias RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151
Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria.
Clavulanic Acid
🥰Excellent
Catalog No. T19860Alias RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151Cas No. 58001-44-8
Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $39 | In Stock | |
| 25 mg | $55 | In Stock | |
| 50 mg | Inquiry | In Stock |
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Purity:≥98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Clavulanic Acid(RX-10100), a major beta-lactam antibiotic produced by the organism Streptomyces claveris, is a potent bacterial beta-lactamase inhibitor used in the study of infections caused by bacteria. Clavulanic Acid has a broad spectrum of biological activity and is active against a wide variety of Gram-positive and Gram-negative bacteria. |
| In vitro | Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase[2]. Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL[4]. |
| In vivo | In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs[4]. In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model[4]. In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects[3]. |
| Alias | RX-10100, MM-14151, MM14151, MM 14151, BRL-14151, BRL14151, BRL 14151 |
| Molecular Weight | 199.16 |
| Formula | C8H9NO5 |
| Cas No. | 58001-44-8 |
| Smiles | [H][C@@]12CC(=O)N1[C@@H](C(O)=O)\C(O2)=C\CO |
| Relative Density. | 1.65 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (50.21 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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